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Mayıs, 2024 tarihine ait yayınlar gösteriliyor

In the brain at rest, neurons rehearse future experience

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New research sheds light on how individual neurons in the hippocampus of rats stabilize and tune spatial representations during periods of rest following the animals' first time running a maze, offering first proof of neuroplasticity during sleep. http://dlvr.it/T7gkP2

Research finds improving AI large language models helps better align with human brain activity

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With generative artificial intelligence (GenAI) transforming the social interaction landscape in recent years, large language models (LLMs), which use deep-learning algorithms to train GenAI platforms to process language, have been put in the spotlight. A recent study found that LLMs perform more like the human brain when being trained in more similar ways as humans process language, which has brought important insights to brain studies and the development of AI models. http://dlvr.it/T7gX87

Hitting the target with non-invasive deep brain stimulation: Potential therapy for addiction, depression, and OCD

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Researchers have successfully tested a novel technique for probing deep into the human brain, without surgery, for potential therapeutic purposes. In the rapidly evolving field of neuroscience, non-invasive brain stimulation is a new hope for understanding and treating a myriad of neurological and psychiatric conditions without surgical intervention or implants. http://dlvr.it/T7ZmYQ

Brain damage reveals part of the brain necessary for helping others

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Our willingness to help others is governed by a specific brain region pinpointed by researchers in a study of patients with brain damage to that region. http://dlvr.it/T7ZYfs

From ripples to daydreams: The brain activity behind mind wandering

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Researchers have found that a specific pattern of brain activity, known as 'sharp-wave ripples,' is associated with thoughts that wander from the present situation. This activity begins in the hippocampus, a crucial brain region for memory formation and recall, and is linked to more vivid and less desirable thoughts. A better understanding of the relationship between sharp-wave ripples and these kinds of thoughts might be helpful for treating related conditions. http://dlvr.it/T7ZJFX

Caffeine affects brain dopamine function in patients with Parkinson's disease

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Regular high caffeine consumption affects dopamine function in patients with Parkinson's disease, shows a new international study. Caffeine consumption before undergoing diagnostic brain dopamine imaging may also affect the imaging results. http://dlvr.it/T7YYdq

Prenatal exposure to air pollution associated with increased mental health risks

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A baby's exposure to air pollution while in the womb is associated with the development of certain mental health problems once the infant reaches adolescence, new research has found. The study examined the long-term mental health impact of early-life exposure to air and noise pollution. http://dlvr.it/T7XCrW

Scientists uncover new molecular drivers of Alzheimer's

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At least 5.8 million Americans are currently living with Alzheimer's disease, which is the most common form of dementia. There is no cure for Alzheimer's, in part because scientists do not yet have a full understanding of what causes the disease. But a new study is shedding light on the molecular drivers that could contribute to Alzheimer's progression. http://dlvr.it/T7RKFc

Researchers unveil shared and unique brain molecular dysregulations in PTSD and depression

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Researchers analyzed multi-omic data from 231 people with PTSD or depression to uncover distinct molecular differences that might affect systems such as the nervous and immune systems, to contribute to these mental health conditions. http://dlvr.it/T7MkvJ

Tracking the cellular and genetic roots of neuropsychiatric disease

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A new analysis has revealed detailed information about genetic variation in brain cells that could open new avenues for the targeted treatment of diseases such as schizophrenia and Alzheimer's disease. http://dlvr.it/T7Mklf

Brain connectivity patterns differ in infants at familial risk for autism

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A study has found distinct brain connectivity patterns in six-week-old infants at risk for developing autism spectrum disorder (ASD). http://dlvr.it/T7MY15

Key differences in brain development between autistic boys and girls

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A new study finds key differences in the development of the cortex between autistic boys and girls ages 2-13. The study found sex-specific changes in the thickness of the outer layer of the brain, called the cortex. http://dlvr.it/T7MKbj

Flicker stimulation shines in clinical trial for epilepsy

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Researcher leads a new clinical trial testing her flicker technology on patients with epilepsy. http://dlvr.it/T7M2Hk

Study explains why the brain can robustly recognize images, even without color

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New research offers a possible explanation for how the brain learns to identify both color and black-and-white images. The researchers found evidence that early in life, when the retina is unable to process color information, the brain learns to distinguish objects based on luminance, rather than color. http://dlvr.it/T7JpkM

Study uncovers cell type-specific genetic insights underlying schizophrenia

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New research provides a map for how the genes known to increase risk of schizophrenia affect specific cells within the brain -- information researchers hope can drive the development of new, effective treatments. http://dlvr.it/T7JpQt

Study models how ketamine's molecular action leads to its effects on the brain

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New research addresses a gap in understanding how ketamine's impact on individual neurons leads to pervasive and profound changes in brain network function. http://dlvr.it/T7HkGp

Cortex's self-organizing abilities in neural development

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Researchers have investigated how highly organized patterns of neural activity emerge during development. http://dlvr.it/T7HjqB

Ancient viral DNA in the human genome linked to major psychiatric disorders

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New research has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression. http://dlvr.it/T7GhdP

New method to reveal what drives brain diseases

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The brain is often referred to as a 'black box'-- one that's difficult to peer inside and determine what's happening at any given moment. This is part of the reason why it's difficult to understand the complex interplay of molecules, cells and genes that underlie neurological disorders. But a new CRISPR screen method has the potential to uncover new therapeutic targets and treatments for these conditions. http://dlvr.it/T7CLXh

Exercise spurs neuron growth and rewires the brain, helping mice forget traumatic and addictive memories

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Researchers have found that increased neuron formation and the subsequent rewiring of neural circuits in the hippocampus through exercise or genetic manipulation helps mice forget traumatic or drug-associated memories. The findings could offer a new approach to treating mental health conditions like post-traumatic stress disorder or drug addiction. http://dlvr.it/T7BYMv

Unique brain circuit is linked to Body Mass Index

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Why can some people easily stop eating when they are full and others can't, which can lead to obesity? A new study has found one reason may be a newly discovered structural connection between two regions in the brain that appears to be involved in regulating feeding behavior. These regions involve the sense of smell and behavior motivation.The weaker the connection between these two brain regions, the higher a person's Body Mass Index, the scientists report. http://dlvr.it/T79D3R

Researchers develop 'game-changing' blood test for stroke detection

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Stroke is the leading cause of disability worldwide and the second leading cause of death, but the right early intervention can prevent severe consequences. Scientists developed a new test by combining blood-based biomarkers with a clinical score to identify patients experiencing large vessel occlusion (LVO) stroke with high accuracy. http://dlvr.it/T74vl3

Under stress, an observer is more likely to help the victim than to punish the perpetrator

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Being stressed while witnessing injustice may push your brain towards altruism, according to a new study. http://dlvr.it/T74Jrd

Different brain structures in females lead to more severe cognitive deficits after concussion than males

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Important brain structures that are key for signaling in the brain are narrower and less dense in females, and more likely to be damaged by brain injuries, such as concussion. Long-term cognitive deficits occur when the signals between brain structures weaken due to the injury. The structural differences in male and female brains might explain why females are more prone to concussions and experience longer recovery from the injury than their male counterparts. http://dlvr.it/T71TwW

Singing repairs the language network of the brain after a cerebrovascular accident

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Singing rehabilitates speech production in post-stroke aphasia. Researchers investigated the rehabilitative effect of singing on the brain. http://dlvr.it/T71TbC

How does the brain turn waves of light into experiences of color?

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Perceiving something -- anything -- in your surroundings is to become aware of what your senses are detecting. Today, neuroscientists identify, for the first time, brain-cell circuitry in fruit flies that converts raw sensory signals into color perceptions that can guide behavior. http://dlvr.it/T70TQk

Artificial intelligence tool detects male-female-related differences in brain structure

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Artificial intelligence (AI) computer programs that process MRI results show differences in how the brains of men and women are organized at a cellular level, a new study shows. These variations were spotted in white matter, tissue primarily located in the human brain's innermost layer, which fosters communication between regions. http://dlvr.it/T700Kt

'Trojan horse' weight loss drug more effective than available therapies

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A groundbreaking article describes a promising new therapy for obesity that leads to greater weight loss in mice than existing medications. The approach smuggles molecules into the brain's appetite center and affects the brain's neuroplasticity. http://dlvr.it/T6zh51

Research sheds light on how proteins linked to Alzheimer's disease influence neuronal growth

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New research has shed light in the complex interplay between cell proteins, and how they impact on neurons in neurodevelopmental disorders and Alzheimer's disease. http://dlvr.it/T6xZ5C

An astrocytic pH regulator that can repair the blood-brain barrier and reverse brain damage caused by ischemic stroke

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A recent study has found that an ion transporter protein that regulates the pH of specific brain cells can repair the blood-brain barrier and restore normal brain function after ischemic stroke. The study has revealed novel and specific therapeutic targets for ischemic stroke and related brain conditions for which no targeted treatments exist currently. http://dlvr.it/T6xKMs

Some brain cells age faster and are more prevalent in Alzheimer's

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Engineers have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer's disease. Additionally, researchers observed male-female-specific differences in the aging process of certain brain cells, with the female cortex exhibiting a higher ratio of 'old' oligodendrocytes to 'old' neurons compared to the male cortex. The discoveries were made possible by a new technique called MUSIC (multinucleic acid interaction mapping in single cells), which allows researchers to peek inside individual brain cells and map out interactions between chromatin--which is the tightly coiled form of DNA -- and RNA. http://dlvr.it/T6tdQz

Innovative 'mini-brains' could revolutionize Alzheimer's treatment

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New research could revolutionize the way Alzheimer's and other brain-related diseases are diagnosed and treated -- by building tiny brains in a petri dish. http://dlvr.it/T6tKgC

Study reveals patients with brain injuries who died after withdrawal of life support may have recovered

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Analysis of 1,392 patients with traumatic brain injuries (TBIs) found that some patients for whom life support was withdrawn may have survived and recovered some level of independence a few months after injury. Families are often asked to make decision to withdraw life support within 72 hours of a brain injury, and the new study suggests delaying decisions may be beneficial for some patients. http://dlvr.it/T6qHfY

Study shows heightened sensitivity to PTSD in autism

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A new study shows that a mild stress is enough to trigger post-traumatic stress disorder (PTSD) in mouse models of autism spectrum disorder (ASD). Researchers demonstrated that the two disorders share a reciprocal relationship, identifying a predisposition to PTSD in ASD, and discovering that core autism traits are worsened when traumatic memories are formed. http://dlvr.it/T6jSLr

Brain mechanisms underlying sensory hypersensitivity in a mouse model of autism spectrum disorder

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A research team has identified the primary cause of sensory hypersensitivity in a mouse model of autism spectrum disorders (ASD). http://dlvr.it/T6jSCJ

How the brain is flexible enough for a complex world (without being thrown into chaos)

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Many neurons exhibit 'mixed selectivity,' meaning they can integrate multiple inputs and participate in multiple computations. Mechanisms such as oscillations and neuromodulators recruit their participation and tune them to focus on the relevant information. http://dlvr.it/T6j6h8

A fragment of human brain, mapped in exquisite detail

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Researchers have created the largest synaptic-resolution, 3D reconstruction of a piece of human brain to date, showing in vivid detail each cell and its web of neural connections in a piece of human temporal cortex about half the size of a rice grain. http://dlvr.it/T6gBzh

High school student helps transform 'crazy idea' into innovative research tool

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A 'crazy idea' hatched during a walk in the woods and first tested by a high school student is now an innovative research tool used by scientists worldwide to predict neurotransmitters in fruit fly connectomes. http://dlvr.it/T6gBhY

Childhood maltreatment responsible for up to 40 percent of mental health conditions

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A study has found the widespread impact of child abuse and neglect, with analysis suggesting they cause nearly half of common mental conditions. Researchers say childhood maltreatment should be treated as a public health priority. http://dlvr.it/T6fbwM

How psychedelic drugs interact with serotonin receptors to potentially produce therapeutic benefits

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Researchers have shed valuable light on the complex mechanisms by which a class of psychedelic drugs binds to and activates serotonin receptors to produce potential therapeutic effects in patients with neuropsychiatric disorders such as depression and anxiety. http://dlvr.it/T6fbZk

Why getting in touch with our 'gerbil brain' could help machines listen better

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Researchers have debunked a 75-year-old theory about how humans determine where sounds are coming from, and it could unlock the secret to creating a next generation of more adaptable and efficient hearing devices ranging from hearing aids to smartphones. http://dlvr.it/T6cRdW

'Mathematical microscope' reveals novel, energy-efficient mechanism of working memory that works even during sleep

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Researchers have discovered a mechanism that creates memories while reducing metabolic cost, even during sleep. This efficient memory occurs in a part of the brain that is crucial for learning and memory, and where Alzheimer's disease begins. http://dlvr.it/T6c72Y

Human 'neural compass' pinpointed in new study

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A pattern of brain activity that helps prevent us from getting lost has been identified in a new study. http://dlvr.it/T6c6b5

Breakthrough paves the way for next generation of vision implants

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A group of researchers have created an exceptionally small implant, with electrodes the size of a single neuron that can also remain intact in the body over time -- a unique combination that holds promise for future vision implants for the blind. http://dlvr.it/T6bk8s

Genetics, not lack of oxygen, causes cerebral palsy in quarter of cases

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The world's largest study of cerebral palsy (CP) genetics has discovered genetic defects are most likely responsible for more than a quarter of cases in Chinese children, rather than a lack of oxygen at birth as previously thought. http://dlvr.it/T6YrYj

New study reveals age-related brain changes influence recovery after stroke

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A new study has revealed that areas of age-related damage in the brain relate to motor outcomes after a stroke -- a phenomenon that may be under-recognized in stroke research. The new observational study looked at the relationship between stroke recovery and white matter hyper-intensities (WMHs) -- areas of age-related damage in the brain's white matter, which represent vascular dysfunction and are known to impact cognitive functions. http://dlvr.it/T6Vtzg

Small molecule shows early-stage promise for repairing myelin sheath damage

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A breakthrough study appears to overcome difficulties that have long frustrated previous attempts to reverse a form of nerve damage that robs people with MS of motor control and gradually blunts cognitive functions for many people as they age. http://dlvr.it/T6Vtky

How the brain's arousal center helps control visual attention too

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Neuroscientists have artificially increased neuronal activity in part of the brain by briefly shining light on genetically modified neurons. They saw that this manipulation selectively enhanced performance in non-human primates performing a visual attention task, underscoring the crucial role that attention plays in sensory perception. http://dlvr.it/T6NDxb

Low intensity light to fight the effects of chronic stress

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Some neurological disorders can be improved through photobiomodulation, a non-invasive technique based on the application of low-intensity light to stimulate altered functions in specific regions of the body. Now, a study reveals how photobiomodulation applied to the brain-gut axis is effective in recovering some cognitive alterations and sequelae caused by chronic stress. The study opens up new perspectives for applying the technique in future therapies for the treatment of neurological diseases in patients. http://dlvr.it/T6L30z

Nutrient research reveals pathway for treating brain disorders

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The team discovered that an essential nutrient called choline is transported into the brain, across the blood-brain barrier, by a protein transporter called FLVCR2. This is discovery will inform future design of drugs for diseases such as Alzheimer's and stroke, mimicking choline so they can be smuggled into the brain. http://dlvr.it/T6Hx3c