Uncovering new details of the brain's first line of defense

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A research team has mapped out the development and genetic trajectory of previously understudied macrophages associated with the central nervous system. Among other things, the team found that meningeal macrophages are formed during gestation and develop in the same way as microglia, while perivascular macrophages develop after birth. Their new insights could pave the way for better understanding the origins and mechanisms behind leading brain-related pathologies such as Alzheimer's disease.
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